TerminatedNot Applicable

Reduction of Oxygen After Cardiac Arrest

Stopped: Pandemic reduced enrolment and changed clinical protocols

Australia428 participantsStarted 2017-12-11

Plain-language summary

The Reduction of oxygen after cardiac arrest (EXACT) is a multi-centre, randomised, controlled trial (RCT) to determine whether reducing oxygen administration to target an oxygen saturation of 90-94%, compared to 98-100%, as soon as possible following successful resuscitation from OHCA improves outcome at hospital discharge.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults (age 18 years or older) * Out-of-hospital cardiac arrest of presumed cardiac cause * All cardiac arrest rhythms * Unconscious (Glasgow Coma Scale \<9) * Return of spontaneous circulation * Pulse oximeter measures oxygen saturation at ≥95% with oxygen flow set at \>10L/min or FiO2 at 100% * Patient has an endotracheal tube (ETT) or supraglottic airway (SGA) (e.g. laryngeal mask airway -LMA) and is spontaneously breathing or ventilated * Transport is planned to a participating hospital Exclusion Criteria: * Female who is known or suspected to be pregnant * Dependent on others for activities of daily living (i.e. facilitated care or nursing home residents) * "Not for Resuscitation" order or Advanced Care Directives in place * Pre-existing oxygen therapy (i.e. for COPD) * Cardiac arrest due to drowning, trauma or hanging

What they're measuring

Survival to hospital discharge

Timeframe: At hospital discharge, participants will be followed for the duration of hospital stay, an expected average of 2-4 weeks

Trial details

NCT IDNCT03138005

SponsorMonash University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-08-05

View on ClinicalTrials.gov More Out-of-Hospital Cardiac Arrest trials