Reduction of Oxygen After Cardiac Arrest (NCT03138005) | Clinical Trial Compass
TerminatedNot Applicable
Reduction of Oxygen After Cardiac Arrest
Stopped: Pandemic reduced enrolment and changed clinical protocols
Australia428 participantsStarted 2017-12-11
Plain-language summary
The Reduction of oxygen after cardiac arrest (EXACT) is a multi-centre, randomised, controlled trial (RCT) to determine whether reducing oxygen administration to target an oxygen saturation of 90-94%, compared to 98-100%, as soon as possible following successful resuscitation from OHCA improves outcome at hospital discharge.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults (age 18 years or older)
* Out-of-hospital cardiac arrest of presumed cardiac cause
* All cardiac arrest rhythms
* Unconscious (Glasgow Coma Scale \<9)
* Return of spontaneous circulation
* Pulse oximeter measures oxygen saturation at ≥95% with oxygen flow set at \>10L/min or FiO2 at 100%
* Patient has an endotracheal tube (ETT) or supraglottic airway (SGA) (e.g. laryngeal mask airway -LMA) and is spontaneously breathing or ventilated
* Transport is planned to a participating hospital
Exclusion Criteria:
* Female who is known or suspected to be pregnant
* Dependent on others for activities of daily living (i.e. facilitated care or nursing home residents)
* "Not for Resuscitation" order or Advanced Care Directives in place
* Pre-existing oxygen therapy (i.e. for COPD)
* Cardiac arrest due to drowning, trauma or hanging
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Survival to hospital discharge
Timeframe: At hospital discharge, participants will be followed for the duration of hospital stay, an expected average of 2-4 weeks