MULTivessel Immediate Versus STAged RevaScularization in Acute Myocardial Infarction -The MULTISTARS AMI Trial

Inclusion Criteria: * Age ≥ 18 years * Spontaneous acute STEMI (patients presenting within 24 hours of symptom onset) * Suitability for PCI from femoral or radial access * Coronary anatomy suitable for complete coronary revascularization with Synergy® stent implantation * Identifiable culprit lesion/artery * At least one non-culprit coronary stenosis ≥ 70% in at least two projections, in a vessel with a lumen diameter ≥2.25 - ≤5.75 mm, other than the culprit artery * TIMI Flow 3 or TIMI flow 2 after revascularization of the culprit artery * Stable hemodynamics at the end of the culprit vessel revascularization Exclusion Criteria: * Inability to give informed consent * Cardiogenic shock * Prolonged resuscitation \>10 min * General unsuitability for PCI * Need for emergency CABG * Previous CABG * Planned hybrid revascularization * Coronary artery dissection * STEMI due to ST * Previous documented allergic reaction to everolimus or to any stent material * Severe mechanical complication of acute myocardial infarction * Pre-existing severe renal failure (eGFR \<30 mL/min) or renal replacement therapy * Chronic total occlusion of a major coronary artery * Left main stem stenosis ≥50% or left main stem equivalent (ostial left anterior descending and ostial circumflex stenosis ≥70%) * In-stent restenosis * Panned coronary, cerebrovascular, or peripheral arterial revascularization * Planned cardiac or major surgery * Any contraindications for dual antiplatelet therapy with aspirin …