CompletedNot Applicable

Sinusoidal Obstruction Syndrome for Stem Cell Transplant Patients Biomarker Study

United States80 participantsStarted 2017-04-01

Plain-language summary

The goal of this is to learn more about stem cell transplant and complications that some people have after their transplants, in particular sinusoidal obstruction syndrome (SOS), also called veno-occlusive disease of the liver.

Who can participate

Age range25 Years

SexALL

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Inclusion criteria

✓. History of hepatic disease as defined by:
✓. Viral hepatitis (i.e., hepatitis C virus \[HCV\])
✓. Liver tumor before HCT
✓. Hepatic fibrosis or cirrhosis before HCT as proven by liver biopsy
✓. High aspartate aminotransferase (AST) (\> 2x ULN) before HCT (pre-transplant evaluation)
✓. High alanine transaminase (ALT) (\> 2x ULN) before HCT
✓. High bilirubin (\> 1.2x ULN) before HCT
✓. HCT high-risk features including:

What they're measuring

SOS proteomic markers

Timeframe: Until the end of the study evaluation, day 180

Trial details

NCT IDNCT03132337

SponsorIndiana University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-01-14

View on ClinicalTrials.gov More Sinusoidal Obstruction Syndrome trials