In the proposed study the investigators aim to clarify the relative contribution of these different mechanisms to the progression of atrial fibrillation (AF). Also the contribution of the individual genetic background will be investigated. Furthermore, the investigators aim to identify clinical parameters and biomarkers informing on the main mechanisms of AF progression in atrial tissue. For this purpose, in all included patients atrial biopsies will be taken during cardiac surgery.
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Biochemical factors in atrial biopsies and blood samples
Timeframe: 2.5 year follow up
Molecular factors in atrial biopsies and blood samples
Timeframe: 2.5 year follow up
Genetic factors in atrial biopsies and blood samples
Timeframe: 2.5 year follow up