Differences in Cannabis Impairment and Its Measurement Due to Route of Administration

Inclusion Criteria: * Be in good general health based on a physical examination, medical history, vital signs, 12-lead ECG and screening urine and blood tests * Test negative for recent cannabis use in urine at the screening visit (confirmed by Gas Chromatography (GC)/ Mass Spectrometry (MS) laboratory test) and at clinic admission * Test negative for other drugs of abuse, including alcohol at the screening visit and at clinic admission * Demonstrate ability to expectorate 3-5 mL of "native" oral fluid over a 5-minute period * Not be pregnant or nursing (if female). All females must have a negative serum pregnancy test at the screening visit and a negative urine pregnancy test at clinic admission. * Have a body mass index (BMI) in the range of 19 to 36 kg/m2 * Blood pressure at Screening Visit does not exceed a systolic blood pressure (SBP) of 150 mmHg or a diastolic blood pressure (DBP) of 90 mmHg * Have no allergies to any of the ingredients used to prepare cannabis brownies (chocolate, eggs, wheat, etc.). * Report prior experience inhaling cannabis (either via smoking or vaporization). Exclusion Criteria: * History of or current evidence of significant medical or psychiatric illness judged by the investigator to put the participant at greater risk of experiencing an adverse event due to exposure or completion of other study procedures. * Use of an Over-the-Counter (OTC), systemic or topical drug(s), herbal supplement(s), or vitamin(s) within 14 days of experimental sess…