Treprostinil Iontophoresis in Systemic Sclerosis Digital UlcErations. A Proof of Concept Study

Inclusion Criteria: Healthy Volunteers: * Age of at least 18 years * Existence of a contraceptive method for women of child-bearing age * Person affiliated to social security or beneficiary of such a scheme * Signed consent form Systemic sclerosis patients: * Systemic sclerosis meeting the EULAR criteria. * Presence of 1 ischemic digital cutaneous ulceration , with digital ulcer classified as "active ulcers" according to the North American working group definition: epithelial denudation is clearly Visible at one place and the bed of de-epithelialized ulcer can be seen; Ulcerations distal to the proximal interphalangeal joint, not associated with calcinosis or bony relief. * Ulcers whose major axis measured with the electronic caliper is ≥ 2 mm * Age greater than or equal to 18 years * Existence of a contraceptive method for women of reproductive age * A person who is or is a beneficiary of social security * Informed and signed consent signed by the patient or his / her legal representative. Exclusion Criteria: Healthy Volunteers * Treprostinil contraindications: Known hypersensitivity to treprostinil or any of the excipients, Pulmonary arterial hypertension related to veno-occlusive disease, Congestive heart failure due to severe left ventricular dysfunction, Severe hepatic insufficiency (Child-Pugh stage C), Evolving gastrointestinal ulcer, intracranial hemorrhage, recent trauma or other clinical condition that may lead to bleeding, Congenital or acquired valvular abn…