CompletedNot Applicable

Rehabilitative Trial With Cerebello-Spinal tDCS in Neurodegenerative Ataxia

Italy21 participantsStarted 2017-02-06

Plain-language summary

Neurodegenerative cerebellar ataxias represent a group of disabling disorders for which we currently lack effective therapies. Cerebellar transcranial direct current stimulation (tDCS) is a non-invasive technique, which has been demonstrated to modulate cerebellar excitability and improve symptoms in patients with cerebellar ataxias. In this randomized, double-blind, sham-controlled study, the investigators will evaluate whether a two-weeks' treatment with cerebellar anodal tDCS and spinal cathodal tDCS can improve symptoms in patients with neurodegenerative cerebellar ataxia and can modulate cerebello-motor connectivity, at short and long term.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * Patients with a cerebellar syndrome and quantifiable cerebellar atrophy Exclusion Criteria: * Severe head trauma in the past * History of seizures * History of ischemic stroke or hemorrhage * Pacemaker * Metal implants in the head/neck region * Severe comorbidity * Intake of illegal drugs * Pregnancy

What they're measuring

Change in the International Cooperative Ataxia Rating Scale (ICARS) Score From Baseline

Timeframe: Baseline - 2 weeks

Change in the Scale for the Assessment and Rating of Ataxia (SARA) Score From Baseline

Timeframe: Baseline - 2 weeks

Trial details

NCT IDNCT03120013

SponsorAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-12-01

Results submitted2018-05-23

View on ClinicalTrials.gov More Ataxia, Cerebellar trials