Identifying Therapeutic Targets of Accelerated Sarcopenia
United States95 participantsStarted 2017-05-28
Plain-language summary
The proposed research is designed to identify the mechanisms that can accelerate loss of muscle size, strength and physical function in type 2 diabetes and with hospitalization in older persons. About ⅓ of older Americans have type 2 diabetes, and about ⅓ of the hospitalizations in the USA involve persons older than 65 year of age. The proposed research is relevant to the part of NIH's mission that pertains to development of the fundamental knowledge that will improve health and reduce the burdens of disability, because this work will provide the fundamental evidence to identify new targets for the development of innovative treatments to slow down muscle loss and disability in our aging society.
Who can participate
Age range
60 Years – 85 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Body mass index: \<40 kg/sq meter
* Score ≥26 on the 30-item Mini Mental State Examination
* Stable body weight for at least 3 months
* Non-diabetic or with Type 2 Diabetes Mellitus
Exclusion Criteria:
* Pre-diabetes per American Diabetes Association criteria
* Insulin therapy, significant diabetic complications, or A1c\>8%
* Impairment in Activities of Daily Living
* \>2 falls/year
* weight loss \>5% in the past 6 months
* Exercise training (≥2 sessions/week) or ≥10,000 steps/day
* Significant cardiovascular, liver, renal, blood, or respiratory disease
* Active cancer or infection
* Recent (within 3 months) treatment with anabolic steroids, systemic corticosteroids or estrogen.
* Alcohol or drug abuse
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Leg Lean Mass
Timeframe: Change from baseline to up to 3 months
Trial details
NCT IDNCT03118050
SponsorThe University of Texas Medical Branch, Galveston