UnknownNot Applicable

Personalized Non-invasive Neuromodulation by rTMS for Chronic and Treatment Resistant Catatonia

France17 participantsStarted 2017-04-24

Plain-language summary

Investigators hypothesize that personalizing rTMS targets using functional MRI will allow to improve symptoms of patients suffering from chronic catatonia.

Who can participate

Age range18 Years – 70 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria: * Aged from 18 to 70 Y * Affiliated to the health insurance * Having signed an informed consent * Suffering from catatonia according to the DSM5, unremitted since \> 2Y * Unresponsive or incomplete remission after at least one trial of benzodiazepine and/or Electroconvulsivotherapy * Treatment stable for \> 6 weeks Exclusion criteria: * Contraindication for MRI, rTMS or tDCS: non-removable ferromagnetic body, prosthesis, pacemaker, medication delivered by an implanted pump clip or vascular stent, heart valve or ventricular shunt, seizure disorders, skin pathology in the region of tDCS electrode placement. * Pregnancy * Severe and non-stabilized somatic pathology * Patients deprived of liberty or hospitalized without their consent * Patients unable to give informed consent.

What they're measuring

Clinical global impression (change in severity and improvement)

Timeframe: In term of percentage reduction in symptoms, difference between before (assessed on D1) and after (assessed on D5 to 7) and at 1 month after each therapeutic protocol (D = day of the beginning of the protocol)

Trial details

NCT IDNCT03116425

SponsorUniversity Hospital, Strasbourg, France

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-06

View on ClinicalTrials.gov More Schizophreniform Catatonia trials