Prospective German Very High Cardiovascular Risk Patients Dyslipidemia Treatment Indication Registry

Inclusion Criteria: * • with familial, homozygous hypercholesterolemia, in whom pharmaceutical and diet options for lipid lowering have proved insufficient, or * with confirmed familial, heterozygous hypercholesterolemia under consideration of the total familial risk, or * with heterozygous familial or non- familial hypercholesterolemia or mixed dyslipidemia with * therapy refractory course * maximal dietary and pharmaceutical lipid lowering therapy - in any case documented over a 12-month period * unsatisfactorily lowered LDL-C value (and thus with an indication for LDL apheresis) * confirmed vascular disease * other risk factors for cardiovascular events Exclusion Criteria: * Concurrent participation of the patient in a clinical randomised study.