Corneal Endothelial Cell Loss After Trabeculectomy Versus Phakotrabeculectomy (NCT03107000) | Clinical Trial Compass
CompletedNot Applicable
Corneal Endothelial Cell Loss After Trabeculectomy Versus Phakotrabeculectomy
Canada25 participantsStarted 2017-09-01
Plain-language summary
Corneal endothelial cells health and pumping function is crucial to permit corneal optical clarity by keeping cornea in relatively dehydrated state. Corneal endothelial damage has been associated with most types of intraocular surgery. Trabeculectomy is the standard glaucoma surgical intervention in management of progressive glaucoma despite of medical therapy which can be performed in combination with Cataract surgery (Phacoemulsification and IOL implantation) in patients with cataract-impaired visual acuity.
In this study, the investigators will investigate and compare the corneal endothelial cells number and health status before and after trabeculectomy vs. combined surgery (at 1 month and 3 months post-op visits) using Specular microscopy which is a non-invasive technique to access the structure and function of the corneal endothelium by permitting visualization of the corneal endothelial mosaic to assess the effect of this surgical intervention on corneal endothelial cells health and number.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Age over 18 y/o.
✓. Patients with well established Open Angle Glaucoma including Primary open angle glaucoma, Pseudoexfoliation or Pigmentary Glaucoma \& Steroid induced Glaucoma requiring incisional surgery for Intraocular pressure higher than target, despite receiving maximal tolerable medical treatment or were intolerant to medications with progressive glaucoma related visual field defects or optic nerve changes.
✓. Any of a above who needs cataract surgery
✓. In those specular microscopy can be performed without any delay in their treatment.
✓. Decision makers able to give informed consent.
Exclusion criteria
✕. Unable to attend follow -up visits.
✕. Angle closure glaucoma.
✕. Secondary open angle glaucoma other than PXFG, PG or SIG.
✕. Previous intraocular surgery/laser procedures other than laser trabeculoplasty.