CompletedPhase 2

Evaluating the Role of Neuroinflammation in Low Back Pain

United States60 participantsStarted 2017-10-10

Plain-language summary

In this research, the study team will use brain imaging to evaluate the presence of neuroinflammation in the brains and spinal cords of patients with low back pain. The efficacy of minocycline use for low back pain treatment will also be evaluated by observing whether short-term minocycline administration will reduce neuroinflammation and low back pain symptoms.

Who can participate

Age range18 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * the ability to give written informed consent * fluency in English * on a stable pain treatment * Chronic or sub-acute low back pain Exclusion Criteria: * no interventional pain procedures during drug trial * contraindications to MRI and PET scanning (including presence of a cardiac pacemaker or pacemaker wires, metallic particles in the body, vascular clips in the head or previous neurosurgery, prosthetic heart valves, claustrophobia) * pregnancy or breast feeding * any use of recreational drugs in the past 6 months * allergy to minocycline or other tetracyclines, or taking medications known to interact with minocycline * any other contraindications to minocycline administration

What they're measuring

Changes in Thalamic Standardized Uptake Value Ratio (SUVR)

Timeframe: The outcome measure was assessed in two time points, before and after a two-week treatment period.

Trial details

NCT IDNCT03106740

SponsorMarco Loggia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-04-30

Results submitted2025-02-05

View on ClinicalTrials.gov More Low Back Pain trials