CompletedNot Applicable

The Neural Correlates of Cannabis Use

United States162 participantsStarted 2016-12

Plain-language summary

The purpose of this research study is to determine the temporal course of recovery of CB1R availability and neural oscillations, in cannabis-dependent individuals at baseline, following 48 hour confirmed inpatient abstinence and after four weeks confirmed abstinence. This research will also examine associations between CB1R availability, neural oscillations and cognitive function.

Who can participate

Age range18 Years – 55 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Cannabis Dependent Subjects * Current cannabis consumption * Willing to abstain from cannabis use for four weeks Inclusion Criteria for Healthy Controls * No current cannabis consumption Exclusion Criteria: * MRI metal exclusions and claustrophobia * Education completed is less than 12 years

What they're measuring

CB1R availability using [11-C]OMAR PET imaging

Timeframe: Change in CB1R availability from baseline to 48 hours and 28 days

Trial details

NCT IDNCT03104257

SponsorYale University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-04-27

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