High-Flow-Therapy for the Treatment of Cheyne-Stokes-Respiration in Chronic Heart Failure

Inclusion Criteria: * NYHA II to IV * LVEF \<= 45% (Echo within 28 days of enrollment) * Predominantly central sleep apnea: AHI ≥15 events per hour, with \>80% central events (apnoea or hypopnoea) and central AHI of ≥10 events per hour * Peak VO2 \< 90% of predicted value (CPX test within 28 days of enrollment) Nocturnal hypoxemic burden ≥ 25min/night * Written informed consent Exclusion criteria: * Daytime hypercapnia (pCO2 \> 45 mmHg) * Ongoing ventilation therapy * Severe COPD (chronic obstructive pulmonary disease) defined as FEV1\< 50% (lung function test within 28 days of enrollment) * Cardiothoracic surgery within the last 3 months * Myocardial infarction within the last 6 months * Unstable angina * Acute myocarditis * Stroke within the last 3 months * Epilepsy or known cerebral damage or dementia * Untreated restless-legs-syndrome * Women of childbearing potential * Participation in any clinical study