CompletedEarly Phase 1

Effect of Age, Weight and Sex on Levothyroxine Pharmacokinetics

41 participantsStarted 2011-05-31

Plain-language summary

This study was a prospective, single-center, open-label, non-randomized, pharmacokinetic study using stable isotope carbon-13 labeled levothyroxine

Who can participate

Age range21 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * age \>21 years at the time of consent * euthyroidism while undergoing treatment with LT4 * no other serious illness * ability to give written informed consent. Exclusion Criteria: * baseline hematocrit lower than 28.0% * TSH greater than 4.5 mIU/L * kidney dysfunction * concomitant use of drugs that affect thyroidal axis interactions

What they're measuring

CL/F

Timeframe: 120 hours

V/F

Timeframe: 120 hours

t-half

Timeframe: 120 hours

Trial details

NCT IDNCT03102177

SponsorGeorgetown University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2013-11-30

View on ClinicalTrials.gov More Hypothyroidism Primary trials