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Central Venous Catheter (CVC) Associated Deep Vein Thrombosis (DVT) in Cancer Patients

Canada70 participantsStarted 2017-05-15

Plain-language summary

Cancer patients with Central Venous Catheter (CVC) Associated Deep Vein Thrombosis (DVT) will be treated with Low Molecular Weight Heparin (LMWH) and apixaban. Study duration is 12 weeks.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Male or female \> 18 years of age.
✓. Symptomatic acute upper limb thrombosis in the axillary, subclavian or internal jugular veins, with or without pulmonary embolism, associated with central venous catheter objectively documented by compression ultrasonography, venogram or Computerized Tomography (CT) scan.
✓. Diagnosis of active malignancy, as defined by patients who are either receiving active treatment, or have metastatic disease or who have been diagnosed within the past two years.
✓. Willing to provide written informed consent.

Exclusion criteria

✕. Presence of dialysis catheters
✕. Active bleeding or high risk for major bleeding
✕. Platelet Count \< 75 x 109/L
✕. Creatinine Clearance \< 30 mL/min
✕. Currently on other anticoagulant with therapeutic intent for another indication
✕. Pulmonary embolism accompanied by hemodynamic instability or oxygen requirement
✕. Inability to infuse through the catheter after a trial of intraluminal thrombolytic therapy (2 mg tPA).
✕. Patients with Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL) or multiple myeloma with a bone marrow or stem cell transplant planned within the next 3 months

What they're measuring

Central Line Failure

Timeframe: within 3 months of study follow-up

Trial details

NCT IDNCT03100071

SponsorMichael Kovacs

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-08

Contact for this trial

Judy Kovacs, RN

519-685-8500 judy.kovacs@lhsc.on.ca

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