CompletedPhase 4

Adductor Canal Block With Periarticular Injection and IPACK (ACB/PAI/IPACK) Versus Periarticular Injection (PAI)

United States86 participantsStarted 2017-02-28

Plain-language summary

A comparison of two pain control methods - the combination of Adductor Canal Block (ACB)/Periarticular Injection (PAI)/Infiltration of the interspace between the popliteal artery and the capsule of the posterior knee (IPACK) versus the Periarticular Injection (PAI) - in patients undergoing total knee arthroplasty. Primary outcome is NRS pain scores with ambulation on postoperative day one (24 hours post-block administration).

Who can participate

Age range18 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients with osteoarthritis scheduled for a primary either partial or total knee arthroplasty with a participating surgeon * Age 18 to 80 years * Planned use of regional anesthesia * Ability to follow study protocol * English speaking (secondary outcomes include questionnaires validated in English only) * Patients of participating surgeons Exclusion Criteria: * Hepatic or renal insufficiency * Younger than 18 years old and older than 80 * Patients undergoing general anesthesia * Allergy or intolerance to one of the study medications * BMI \> 40 * Diabetes * ASA of IV * Chronic gabapentin/pregabalin use (regular use for longer than 3 months) * Chronic opioid use (taking opioids for longer than 3 months, or daily oral morphine equivalent of \>5mg/day for one month) * Patients with severe valgus deformity and flexion contracture

What they're measuring

Numeric Rating Scale (NRS) Pain Scores

Timeframe: 24 hours post block administration

Trial details

NCT IDNCT03094663

SponsorHospital for Special Surgery, New York

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-05-31

Results submitted2022-04-11