Effect of Remote Ischemic Post-conditioning on Out-of-hospital Cardiac Arrest (NCT03093948) | Clinical Trial Compass
TerminatedNot Applicable
Effect of Remote Ischemic Post-conditioning on Out-of-hospital Cardiac Arrest
Stopped: Overlap with other RCT
South Korea58 participantsStarted 2017-03-21
Plain-language summary
Ischemia-reperfusion leads to mitochondrial injury, ion-pump injury, cell membrane damage, cytotoxic edema, and excessive oxygen free radical formation, and eventually destroys cells. Cardiac arrest is an example of global ischemia; after spontaneous circulation is restored, ischemia-reperfusion injury develops in cardiac arrest survivors.
Remote ischemic postconditioning (RIPoC) involves the application of brief, reversible episodes of ischemia and reperfusion to a vascular bed or tissue, rendering remote tissues and organs resistant to ischemia-reperfusion injury. Accordingly, RIPoC has been suggested as adjunctive therapy to mitigate ischemia-reperfusion injury. RIPoC applied by repeated brief inflation-deflation of a blood pressure cuff protects against myocardial injury, and has been proven effective in acute myocardial infarction.
This study aims to perform a randomized controlled trial to determine whether RIPoC has a neuroprotective effect and aids in myocardial recovery in out-of-hospital cardiac arrest patients after restoration of spontaneous circulation.
Neuron-specific enolase (NSE) at 48 hours after restoration of spontaneous circulation will be measured as a primary outcome.
Who can participate
Age range
19 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult (19 years and older)
* comatose out-of-hospital cardiac arrest with sustained restoration of spontaneous circulation
* Undergoing targeted temperature management
* Time of enrollment ≤ 6hrs from restoration of spontaneous circulation
* cardiac arrest from medical cause (cardiac or other medical cause)
Exclusion Criteria:
* Pre-existing dementia, brain injury, or dependence on others (cerebral performance category scale greater than 3)
* Traumatic etiology for cardiac arrest
* Protected population (pregnant, prisoner)
* in-hospital cardiac arrest
* Known bleeding diathesis
* suspected or confirmed acute intracranial hemorrhage
* suspected or confirmed acute ischemic stroke
* Known limitations in therapy and do-not-resuscitate order
* known disease making 180-day survival unlikely
* \>6 hours from restoration of spontaneous circulation to randomization
* cardiac arrest from asphyxia (hanging, foreign body airway obstruction), drowning, drug overdose, or electrocution
* peripheral vascular disease (Deep vein thrombosis, arteriosclerosis obliterans)
* systolic blood pressure \< 80 mmHg in spite of fluid loading/vasopressor and/or inotropic medication
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
neuron specific enolase
Timeframe: at 48 hour after restoration of spontaneous circulation