CompletedNot Applicable

Subgingival Microbiota Following Mechanical Treatment and it's Effect on Peri-implant Sub-mucosa in Periodontitis Patients

China12 participantsStarted 2016-04-01

Plain-language summary

The investigators planed to observe the microbiome of an aggressive periodontitis patient, during mechanical treatment, surgery(if indicated) and implant placement. The investigators designed to observe the changes after mechanical treatment.Then, the investigators will compare the sub-mucosa microbiome of implant and the subgingival community. The investigators expected a different community after treatment, and there could be similarity between implant and nature teeth.

Who can participate

Age range18 Years – 35 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Subjects were between 18-35 years old and diagnosed with generalized aggressive periodontitis (GAgP) according to the 1999 International Classification of Periodontal Diseases (Armitage 1999);
✓. At least 20 teeth in the first appointment and at least 3 teeth(other than first molars and central incisors)with a probing depth(PD) ≥ 6mm, clinical attachment level (CAL)≥5mm;
✓. The clinical diagnosis was confirmed by evidence of inter-proximal bone loss on full-mouth periapical radiographs;
✓. Family history of aggressive periodontitis.

Exclusion criteria

✕. Uncontrolled systemic conditions including diabetes and hypertension;
✕. Pregnant or lactating;
✕. Smoking;
✕. Received periodontal treatment within the previous 6 months or antibiotic medication during the previous 3 months.

What they're measuring

changes of diversity of subgingival community (compare the sub-mucosa microbiome of implant and the subgingival community)

Timeframe: Baseline, 6 weeks after mechanical treatment

changes of diversity of subgingival community (compare the sub-mucosa microbiome of implant and the subgingival community)

Timeframe: before implantation, 1 months after second stage surgery, and every month after prosthetic treatment until 2 years.

changes of prevalence and abundance of OTUs

Timeframe: Baseline, 6 weeks after mechanical treatment

changes of prevalence and abundance of OTUs

Timeframe: before implantation, 1 months after second stage surgery, and every month after prosthetic treatment until 2 years.

Trial details

NCT IDNCT03090282

SponsorPeking University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-12-01

View on ClinicalTrials.gov More Aggressive Periodontitis, Generalized trials

Plain-language summary

Who can participate

Age range18 Years – 35 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Subjects were between 18-35 years old and diagnosed with generalized aggressive periodontitis (GAgP) according to the 1999 International Classification of Periodontal Diseases (Armitage 1999);
✓. At least 20 teeth in the first appointment and at least 3 teeth(other than first molars and central incisors)with a probing depth(PD) ≥ 6mm, clinical attachment level (CAL)≥5mm;
✓. The clinical diagnosis was confirmed by evidence of inter-proximal bone loss on full-mouth periapical radiographs;
✓. Family history of aggressive periodontitis.

Exclusion criteria

✕. Uncontrolled systemic conditions including diabetes and hypertension;
✕. Pregnant or lactating;
✕. Smoking;
✕. Received periodontal treatment within the previous 6 months or antibiotic medication during the previous 3 months.

What they're measuring

changes of diversity of subgingival community (compare the sub-mucosa microbiome of implant and the subgingival community)

Timeframe: Baseline, 6 weeks after mechanical treatment

changes of diversity of subgingival community (compare the sub-mucosa microbiome of implant and the subgingival community)

Timeframe: before implantation, 1 months after second stage surgery, and every month after prosthetic treatment until 2 years.

changes of prevalence and abundance of OTUs

Timeframe: Baseline, 6 weeks after mechanical treatment

changes of prevalence and abundance of OTUs

Timeframe: before implantation, 1 months after second stage surgery, and every month after prosthetic treatment until 2 years.