CompletedNot Applicable

Addiction, HIV and Tuberculosis in Malaysian Criminal Justice Settings

Malaysia316 participantsStarted 2017-08-21

Plain-language summary

The purpose of this study is to conduct empiric studies of tuberculosis (TB) among people in prison with and without a history of opioid dependence. A RCT of latent TB infection prevention strategies among HIV+ and HIV- prisoners with high prevalence of hepatitis C (HCV) using standard 40-week daily isoniazid (40H) vs short-course weekly isoniazid + rifapentine (12HR). Investigators will also use this data, and publicly available data to complete agent-based modeling for comparative and cost-effectiveness of various TB screening and treatment strategies among prisoners.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Inclusion Criteria (screening): * Age ≥ 18 years * Newly admitted inmate at Kajang Prison Inclusion Criteria (Trial): * Age ≥ 18 years HIV-1 seropositivity * Confirmed LTBI (TST ≥ 5mm if HIV+; TST ≥ 10 mm if HIV-) * Meets DSM-V criteria for opioid dependence * \>9 months before release (to ensure treatment completion in prison) * AST/ALT \< 3x upper limit normal Exclusion Criteria: * Unable to provide informed consent * On a protease inhibitor * Women who are pregnant or are planning on becoming pregnant

What they're measuring

TB Treatment Completion Rates in Prison

Timeframe: 3 to 6 months

Trial details

NCT IDNCT03089983

SponsorYale University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-04-04

Results submitted2025-04-02

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