CompletedNot Applicable

Modulating Interaction of Motor Learning Networks in Rehabilitation of Stroke

United States12 participantsStarted 2016-04-01

Plain-language summary

This study uses a form on non-invasive brain stimulation called transcranial magnetic stimulation to understand 1) understand how the brain learns post-stroke and 2) assess non-invasive brain stimulation as an addition to current stroke rehabilitation approaches. In two study arms the investigators will compare the effect of active transcranial magnetic stimulation paired with motor practice with placebo (or sham) transcranial magnetic stimulation paired with the same motor practice.

Who can participate

Age range50 Years – 75 Years

SexALL

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Inclusion criteria

✓. Age between 50-75 years
✓. movement-related deficit associated with first time middle cerebral artery stroke
✓. greater than 6-months post-stroke
✓. Fugl-Meyer score between 15 and 60
✓. ability to elicit a motor evoked potential from the ipsilesional cortex

Exclusion criteria

✕. a score \<27 on the Mini-Mental Status Exam
✕. a score of \<123 on the Mattis Dementia Rating Scale
✕. a score of \<13 on the Frenchay Aphasia Screen
✕. a history of seizure/epilepsy, head trauma, major psychiatric diagnosis, neurodegenerative disorder or substance abuse
✕. a history of congestive heart failure
✕. systolic blood pressure above 120 mmHg and/or diastolic pressure above 80 mmHg
✕. the taking of any GABAergic, NMDA-receptor antagonist or other drug known to influence the neural receptors that facilitate neural plasticity
✕. an infarct resulting from ischemic stroke of anterior or posterior cerebral artery OR an infarct that encroaches within 2cm of the site of cTBS stimulation

What they're measuring

Change From Baseline in Sequential Response Time to Post-Intervention

Timeframe: Baseline and post-intervention

Trial details

NCT IDNCT03086551

SponsorUniversity of Michigan

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-03-30

Results submitted2020-03-12

View on ClinicalTrials.gov More Stroke trials