Sperm Selection by Microfluidic Separation Improves Embryo Quality

Inclusion Criteria: * The target population includes couples planning in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI). * Subjects with and without a history of prior IVF cycles will be included. * All eligible couples where both partners are \>=18 years of age will be asked to join the study. Exclusion Criteria: * Male partner with severe oligoasthenospermia (concentration \< 5 x 10\^6 spermatozoa/mL; motility\< 10%) * Female partner with anovulation (PCOS, FHA) * Female partner age \>41 * Female partner AFC\< 7 * Female partner with obstructed fallopian tubes (assessed in all patients prior to IVF) * Use of oocyte donor * Either Partner: * Cancer diagnosis in either partner * Any significant disease or psychiatric disorder that would interfere with consenting process * Treatment History: o History of \>1 prior cycle cancellation due to poor response * Treatment Plan: * Embryo co-culture * Use of adjunctive non-gonadotropin medications to improve embryo quality: growth hormone, sildenafil