UnknownNot Applicable

Asymptomatic Small Pancreatic Endocrine Neoplasms.

Italy1,000 participantsStarted 2017-09-01

Plain-language summary

The aim of the study is to evaluate the most appropriate management of sporadic asymptomatic non-functioning pancreatic neuroendocrine neoplasms (NF-PNEN) ≤ 2 cm. P NF-PNEN management will be decided at the hospital and all therapeutics decision will be decided/coordinated by the treating physician. Patients will be either submitted to surgical resection or to active surveillance.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age \> 18 years * Individuals with asymptomatic sporadic NF-PNEN ≤ 2 cm * Diagnosis has to be proven by a positive fine-needle aspiration (FNA) or by the presence of a measurable nodule on high-quality imaging technique (CT or MR) that is positive at 68Gallium DOTATOC-PET scan or Octreoscan. * Patients who undergo surgery for NF-PNEN\<2cm within 12 months. In these cases, diagnosis has to be proven by histological confirmation of NF-PNEN * Informed consent Exclusion Criteria: * NF-PNEN \> 2 cm of maximum diameter * Presence of genetic syndrome (MEN1, VHL, NF) * Presence of symptoms (specific symptoms suspicious of a clinical syndrome related to hypersecretion of bioactive compounds) or unspecific symptoms

What they're measuring

Disease/progression-free survival of NF-PNEN ≤ 2 cm

Timeframe: From date of enrolment until the date of first documented progression or first evidence of recurrence, from 6 months up to 6 years.

Trial details

NCT IDNCT03084770

SponsorIRCCS San Raffaele

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-08-31

Contact for this trial

Massimo Falconi, Professor

0039 022643 6046 falconi.massimo@hsr.it

View on ClinicalTrials.gov More Non Functioning Pancreatic Endocrine Tumor trials