CompletedNot Applicable

POCD: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12.

China215 participantsStarted 2017-03-01

Plain-language summary

To study on the Postoperative Cognitive Dysfunction: Correlations With the Gene Polymorphism and the Concentrations of Plasma Homocysteine, Folic Acid and Vitamin B12. To explore whether the gene polymorphism and the concentrations of plasma homocysteine, folic acid and vitamin B12 could be used as predictor(s) of POCD and to provide reference for POCD prevention, early detection and timely diagnosis and treatment.

Who can participate

Age range

60 Years – 85 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Non-cardiac surgery patients; * Age is greater than or equal to 60 years old; * Han Nationality, mother tongue is chinese; * The MMSE score: Illiteracy is greater than or equal to 17 points, primary school is greater than or equal to 20 points, higher secondary school is more than 24 points; * The Geriatric Depression Scale (GDS) grade 1 or 2; * The important function without serious heart, brain, liver, kidney, lung and other organs; * The ASA class I or II; * The people signed informed consent. Exclusion Criteria: * The diagnosis of neurological and psychiatric disorders, such as Alzheimer's disease, Parkinson's syndrome, multiple sclerosis, schizophrenia, depression, etc.; * Had severe head and face disease, trauma history or history of surgery; * The serious body disease and tobacco, wine and other substance abuse history; * The presence of malignant tumor with shorter survival disease.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

the neuropsychological tests

Timeframe: 1 day before surgery(baseline)

Mini-Mental score examination [MMSE]

Timeframe: 1 day before surgery(baseline)

the neuropsychological tests

Timeframe: within the first 7 days (plus or minus 2 days) after surgery

Mini-Mental score examination [MMSE]

Timeframe: within the first 7 days (plus or minus 2 days) after surgery

Trial details

NCT IDNCT03084393

SponsorXuzhou Medical University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2018-04-30

View on ClinicalTrials.gov More Postoperative Cognitive Dysfunction trials

Plain-language summary

Who can participate

Age range

60 Years – 85 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

the neuropsychological tests

Timeframe: 1 day before surgery(baseline)

Mini-Mental score examination [MMSE]

Timeframe: 1 day before surgery(baseline)

the neuropsychological tests

Timeframe: within the first 7 days (plus or minus 2 days) after surgery

Mini-Mental score examination [MMSE]

Timeframe: within the first 7 days (plus or minus 2 days) after surgery