CompletedPhase 1/2

A Preliminary Study About Unexplained Recurrent Miscarriage and Repeated Implantation Failure Patients Treated With Low-dose Lymphocyte Immunotherapy

China292 participantsStarted 2015-03

Plain-language summary

Recurrent miscarriage(RM) and recurrent implantation failure (RIF) are clinical challenge for clinicians and patients who are desperate for a healthy child.The specific etiology contains chromosomal abnormalities, reproductive anatomical abnormalities, endocrine disorders, reproductive system infections, autoimmune and environmental factors. However there are still 50% to 60% RM and RIF which don't have a clear cause,mainly associated with alloimmune factors.Among various treatments,lymphocytes active immunotherapy is the most common treatment method, and its clinical efficacy is widely recognized although its action mechanism is not clear so far.

Who can participate

Age range20 Years – 40 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy except for their history of recurrent abortions and were negative for blocking antibodies * Willing to receive follow up Exclusion Criteria: * Patients with genetic impairment * Patients with Mullerian anomaly * Patients with hormonal deficiency * Patients with metabolic disorder * Patients with infectious disease * Patients with autoimmune abnormalities

What they're measuring

T cell proportion

Timeframe: 1 year

Abortion rate

Timeframe: 1 year

IVF outcomes

Timeframe: 1 year

Trial details

NCT IDNCT03081325

SponsorNanjing University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-06

View on ClinicalTrials.gov More Unexplained Recurrent Miscarriage and Recurrent Implantation Failure trials