Lung MRI in the Management of Idiopathic Pulmonary Fibrosis (NCT03078426) | Clinical Trial Compass
CompletedNot Applicable
Lung MRI in the Management of Idiopathic Pulmonary Fibrosis
France60 participantsStarted 2017-02-16
Plain-language summary
High resolution computed tomography (HRCT) plays a major role in the management of idiopathic pulmonary fibrosis (IPF) by identifying characteristic lesions of usual interstitial pneumonia (UIP). Though HRCT is the standard reference to describe pulmonary structural alterations using a non invasive technique, it is nonetheless a radiating exam which provides limited functional information regarding inflammation. In this trial, the investigators aimed to evaluate whether MRI (Magnetic Resonance Imaging) using ultra-short echotime could be an alternative to HRCT in the assessment of the four morphological criteria required to define an UIP pattern. The investigators also planned to study the clinical value of the additional informations derived from MRI such as contrasts and lung perfusion using functional MRI.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients \> 18 years old followed in Bordeaux University Hospital
* Patients with a definite diagnosis of IPF :
* Based on a "certain" UIP pattern at HRCT without histopathology
* Based on a "possible" UIP pattern at HRCT with histopathology given by surgical lung biopsy.
* Patients with a diagnosis of fibrosing sarcoidosis after multidisciplinary discussion
* Patients with a diagnosis of acute or sub-acute hypersensitivity pneumonitis after multidisciplinary discussion
* Patients diagnosed with organizing pneumonia after multidisciplinary discussion
* Patients with a diagnosis of isolated pleural plaques after multidisciplinary discussion
* Patient able to withstand supine position for more than 30 minutes
* Patient affiliated to a social security system
* Patients who gave their written informed consent
Exclusion Criteria:
* Subject detained by judicial or administrative decision.
* Major protected by law.
* Subject not affiliated to a social security care
* Subject in period of relative exclusion in relation to another protocol.
* Patients with specific contraindication to undergoing MRI: iron material, a heart pacemaker, claustrophobia, gadolinium hypersensitivity, renal impairment with glomerular filtration rate less than 30 mL/min, pregnant or nursing woman.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Measure of the diagnostic's accuracy of lung MRI compared to thoracic HRCT