RecruitingNot Applicable

Open Access Database of Standing Full Body Radiographs in Asymptomatic Volunteers

United States60 participantsStarted 2016-09

Plain-language summary

A study of the skeletal structure and how the structure changes over time. The aim of the study is to evaluate the skeleton in 10 year increments to determine an understanding of the normal skeleton as a person ages. By using x-ray analysis, a new low dose x-ray system (EOS) can be used to evaluate the whole body to see changes in the bone structure over time. Subjects will be asked to undertake one x-ray analysis of their whole body skeletal structure. There will be 25 male and 25 female subjects per decade. The averaging of the measured skeletal parameters will provide information on changes over time generating a standardized expectation of general changes in skeletal structure as participants age.

Who can participate

Age range

21 Years – 85 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Males and females age 21-85 without a history of spine surgery. Exclusion Criteria: * History of spine or neural axis surgery * History of cancer with or without metastatic disease * Connective tissue, rheumatologic (or other inflammatory arthropathies), or neurologic disorders * History of knee replacement surgery, as these may have contractures causing unexpected changes in alignment * Severe osteoarthritis of the hips/knees/ankles * Spondylitis * Compression fractures or other trauma of the spinal column * Previous trauma/fractures of the pelvis whether or not surgery was required * Previous trauma or fractures of the lower extremities requiring surgery * Pregnant women * BMI \>37 * Oswestry Disability Index score \>25

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Coronal plumb-line

Timeframe: Through 1 EOS scan, 20 minutes

Sagittal vertebral axis (SVA)

Timeframe: Through 1 EOS scan, 20 minutes

External auditory meatus plumb-line

Timeframe: Through 1 EOS scan, 20 minutes

Cervical lordosis

Timeframe: Through 1 EOS scan, 20 minutes

Thoracic kyphosis

Timeframe: Through 1 EOS scan, 20 minutes

Lumbar lordosis

Timeframe: Through 1 EOS scan, 20 minutes

Hip flexion/extension

Timeframe: Through 1 EOS scan, 20 minutes

Knee flexion/extension

Timeframe: Through 1 EOS scan, 20 minutes

Trial details

NCT IDNCT03076658

SponsorUniversity of Colorado, Denver

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2031-01

Contact for this trial

David Calabrese

303-524-2550 david.calabrese@ucdenver.edu

View on ClinicalTrials.gov More Intervertebral Disc Degeneration trials

Plain-language summary

Who can participate

Age range

21 Years – 85 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Coronal plumb-line

Timeframe: Through 1 EOS scan, 20 minutes

Sagittal vertebral axis (SVA)

Timeframe: Through 1 EOS scan, 20 minutes

External auditory meatus plumb-line

Timeframe: Through 1 EOS scan, 20 minutes

Cervical lordosis

Timeframe: Through 1 EOS scan, 20 minutes

Thoracic kyphosis

Timeframe: Through 1 EOS scan, 20 minutes

Lumbar lordosis

Timeframe: Through 1 EOS scan, 20 minutes

Hip flexion/extension

Timeframe: Through 1 EOS scan, 20 minutes

Knee flexion/extension

Timeframe: Through 1 EOS scan, 20 minutes