Utility of Cortical Bone Tissue Properties in the Assessment of Fracture Risk

Inclusion Criteria: * Women with hip and wrist fractures within 2 weeks of presentation * Non-fracture controls Exclusion Criteria: * Unable to undergo BMD by DXA or high-resolution peripheral quantitative computed tomography (HR-pQCT) * History of skeletal metastasis, primary hyperparathyroidism, Paget's disease, multiple myeloma * Treatment with bisphosphonate, estrogen (within previous 3 years), teriparatide therapy, calcitonin, selective estrogen receptor modulator (SERMs,within previous 3 years) * Use of glucocorticoids continuously for more than 3 months, use of anticonvulsants * Prior fracture in adulthood (\>age 18) for healthy controls Amendment to protocol added Arm 2, to include males \>50 years with otherwise similar eligibility criteria.