Carbon Dioxide Surgical Field Flooding and Aortic No-touch Off-pump Coronary Artery Bypass Grafting to Reduce Neurological Injuries After Surgical Coronary Revascularization (CANON): a Randomised, Controlled, Investigator and Patient Blinded Single Center Superiority Trial With Three Parallel Arms.

Inclusion Criteria: * elective and/or urgent coronary artery bypass Exclusion Criteria: * emergent and salvage setting * score below age- and education-adjusted cut-off scores in mini mental state examination * score above 8 on the subscales of hospital anxiety and depression scale * neurologic deficit of any etiology * previous psychiatric illness * use of tranquilizers or antipsychotics * alcohol or drug abuse * history of cardiac surgery * left ventricular ejection fraction less than 30% * extracranial carotid artery stenosis of more than 70% * body mass index of more than 35 kg/m2 * any contraindication for magnetic resonance imaging (e.g., magnetic resonance imaging - incompatible implantable device and claustrophobia)