Comparison Between Effect of Conventional, Intensive and Light Emitting Diodes (LED) Phototherapy… (NCT03074292) | Clinical Trial Compass
UnknownNot Applicable
Comparison Between Effect of Conventional, Intensive and Light Emitting Diodes (LED) Phototherapy on Oxidative Stress Among Neonates With Unconjugated Hyperbilirubinemia
120 participantsStarted 2013-12
Plain-language summary
The aim of the present study is to test a hypothesis assuming that phototherapy might have an effect on oxidant/antioxidant status in term and late-preterm neonates with unconjugated hyperbilirubinemia.
Who can participate
Age range2 Days – 28 Days
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Term and late-preterm neonates (≥35weeks) according to the guidelines of the American Academy of Pediatrics (2004) which stated that gestational ages of newborns were determined according to the first day of the mother's last menstrual period (by the mother's statement) and were additionally confirmed by the Ballard scoring system (Ballard et al., 1991) and antenatal ultrasonographic estimation or obstetric records if present.
* Clinical significant indirect hyperbilirubinemia requiring phototherapy in the first week of life.
* Normal blood counts and peripheral blood smears
* Normal reticulocytic count.
* Breast fed newborn.
Exclusion Criteria:
* Those in whom the total serum bilirubin (TSB) level rose by more than 5 mg/dl per day or was higher than 20 mg/dl within the first 24 hours after birth were excluded from the study.
* Infant of diabetic mothers.
* Maternal eclampsia-preeclampsia.
* Birth asphyxia
* Sepsis
* congenital anomalies.
* Direct Coombs'test positive
* Pathological causes of hyperbilirubinemia.
* Enclosed hemorrhage.
* Hemolytic type of hyperbilirubinemia due to blood group or Rh incompatibility.
What they're measuring
1
Effect of types of phototherapy on change in total antioxidant capacity (TAC)
Timeframe: 2 days
2
Effect of types of phototherapy on change in malonaldehyde (MDA)
Timeframe: 2 days
3
Effect of types of phototherapy on change in nitric oxide (NO)