Accuracy and Feasibility of Xpert Ultra

Case Detection Group Inclusion Criteria: * Age 18 years or above; * Provision of informed consent; * Willingness to provide 4 sputum specimens at enrolment; * Willingness to have a study follow-up visit approximately 42 to 70 days after enrolment * Clinical suspicion of pulmonary TB (including cough ≥2 weeks and at least 1 other symptom typical of TB) Exclusion Criteria: * Receipt of any dose of TB treatment within 6 months prior to enrolment * Participants for whom, at the time of enrolment, the follow-up visit is judged to be poorly feasible (e.g. individuals planning to relocate) Drug-Resistant TB Group Inclusion Criteria: * Age 18 years or above; * Provision of informed consent; * Willingness to provide 4 sputum specimens at enrolment; * Non-converting pulmonary TB cases (category I and category II failures) or multi-drug resistant (MDR) suspect\* (based on World Health Organization definition), i.e. at least one of the following: i) retreatment cases, ii) active TB cases that are MDR-contacts and iii) patients at high risk for MDR-TB as determined by local program (e.g. prisoners) Exclusion Criteria: • none