Left Cardiac Sympathetic Denervation for Cardiomyopathy Feasibility Pilot Study

Inclusion Criteria: * At least 18 years of age * New York Heart Association (NYHA) II/III stable heart failure due to an ischemic or non-ischemic cardiomyopathy with a Left Ventricular Ejection Fraction \<=35% based on Echocardiogram, ERNA or MRI performed in the last 12 months. For the purpose of this study, Ischemic cardiomyopathy will be defined as Left Ventricular systolic dysfunction (Ejection Fraction \<35%) associated with 75% narrowing of at least 1 of the 3 major coronary arteries, a documented history of a ST elevation myocardial infarction or significant regional wall motion abnormality on an echocardiogram. Non-ischemic cardiomyopathy will be defined as Left Ventricular systolic dysfunction \<35% in the absence of known coronary artery disease or regional wall motion abnormality on echocardiography. * No history of a prior cardiac arrest or sustained (\>30 seconds or \<30s if haemodynamically unstable) ventricular tachyarrhythmia. * Signed informed consent forms will be available in IsiXhosa, Afrikaans and English. Exclusion Criteria: * History of prior unexplained syncope, sudden cardiac arrest or ventricular arrhythmia * Peripartum cardiomyopathy or cardiomyopathy associated with thyrotoxicosis * History of coronary revascularization or percutaneous intervention in the preceding 3 months * Myocardial infarction in the preceding 1 month * NYHA IV at enrollment * Patient taking an antiarrhythmic drug (not including beta-blockers) * Pregnancy * Any non-cardiac c…