Race, Natriuretic Peptides and Physiological Perturbations

Inclusion Criteria: * 18 to 40 years * Blood pressure less than 140/90 mm Hg * Able to perform exercise capacity test * BMI 18-30 kg/m2 * Willing to adhere to study drug Exclusion Criteria: * History of cardiovascular disease or use of medications for CVD * History of hypertension or use of BP lowering medications * Blood pressure less than 100/60 mm Hg * Heart rate less than 60 beats/min * Depression * Diabetes or use of anti-diabetic medications * Renal disease (eGFR \< 60ml/min/1.73m2) * Current or prior smokers * Pregnant or use of Hormone Replacement Therapy (HRT) or oral contraceptives (OCP) or steroids