CompletedNot Applicable

Myocardial Fibrosis, Function and Aging

France74 participantsStarted 2017-02-20

Plain-language summary

In normal ageing, the impact of myocardial fibrosis on myocardial function is unclear as diastolic function is reported to change according to age. The objective is to explore the relationship between myocardial function changes, with local (T1 and diffusion) fibrosis measures with Magnetic Resonance Imaging (MRI) as well as global measures of fibrosis (skin auto-fluorescence and collagen blood-biomarkers).

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * physical activity ≤ 3 x(30') per week * no history of smoking, diabetes, myocardial infarction, heart failure, hypertension (\<140 or \<90 mmHg) and no anti-hypertensive or cardiovascular-related medications * no familial history of early myocardial ischemia * body mass index (BMI) \<30kg/m2 * normal routine lipid blood analysis * glycemia \<1.26g/l * normal electrocardiogram (ECG) Exclusion Criteria: * arrhythmia * hepatic insufficiency * pregnancy * claustrophobia * MRI contrast allergy, * general contraindications to MRI such as pacemaker, etc.

What they're measuring

Regional myocardial strain

Timeframe: The day of MRI

Trial details

NCT IDNCT03064503

SponsorHospices Civils de Lyon

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-12-05

View on ClinicalTrials.gov More Healthy trials