Stopped: slow enrollment, outcome measures collected but actual enrollment is below target enrollment
The aim of this study is to evaluate the impact of a rotational thromboelastometry (ROTEM®)-based transfusion protocol during postpartum hemorrhage (PPH) after vaginal or cesarean delivery. Maternal transfusion requirement, quantitative blood loss (QBL), need for intensive care unit (ICU) admission, and length of hospital stay will be evaluated. The utilization of ROTEM® for transfusion management will identify patients who develop early coagulation changes such as hypofibrinogenemia or disseminated intravascular coagulation. Our hypothesis is that earlier identification and directed therapy of such coagulation changes will lower overall transfusion requirement (packed red blood cells, fresh frozen plasma, fibrinogen concentrate, cryoprecipitate, or other product), reduce the need for ICU admission, and shorten length of hospital stay. A cost analysis will be performed.
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Total Blood Products Transfused Within 48h of Onset of PPH
Timeframe: t0 = diagnosis of PPH by criteria defined; t final = 48h after onset of PPH.