Effect of Tranexamic Acid (TXA) on Reduction of Postoperative Blood Transfusion (NCT03063892) | Clinical Trial Compass
Active — Not RecruitingPhase 4
Effect of Tranexamic Acid (TXA) on Reduction of Postoperative Blood Transfusion
United States200 participantsStarted 2017-08-30
Plain-language summary
Tranexamic Acid (TXA) is an antifibrolytic medication used in total hip and knee arthroplasty to reduce the need for intraoperative and postoperative blood transfusions. Limited research is available on its use in hip fracture patients. We hypothesize that the use of TXA preoperatively, perioperatively, and postoperatively will decrease blood loss and need for blood transfusion postoperatively.
Who can participate
Age range
60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Over the age of 60 years
* Hip fracture requiring surgical intervention
* Signs consent and agrees to participate
Exclusion Criteria:
* Under the age of 60
* Does not sign consent or refuses participation
* Known hypersensitivity to tranexamic acid
* Multiple acute fractures
* Creatinine clearance \<30
* History of seizures
* Active hormone therapy
* History of coagulation abnormality
* History of deep vein thrombosis (DVT) or pulmonary embolism (PE) within the last year or history or recurrent DVT/PE
* Myocardial infarction (MI) and/or stents within the past year
* History of intracranial hemorrhage
* Acquired defective color vision
* Patients admitted directly to nursing units or surgery without stay in the Emergency Center
* Patients who sustain fracture while hospitalized at ProMedica Toledo Hospital
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
proportion of patients requiring packed Red Blood Cell transfusion