CompletedPhase 1

Effects of Intranasal Oxytocin Administration on Social Influence Effects on Pain

United States51 participantsStarted 2017-06-21

Plain-language summary

This experiment will explore the joint effects of social information, social support, associative learning, and oxytocin on the development of placebo analgesia. The investigators predict that socially transmitted placebo effects will be enhanced by nasal administration of oxytocin, whereas associative learning effects on pain will not be altered by this pharmacological manipulation

Who can participate

Age range18 Years – 40 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Subject is a volunteer between 18 and 40 years of age. * If female, subject is non-lactating, not pregnant, and using a reliable contraception method * Subject is able to read and speak English. * Subject is able and willing to provide written informed consent. * Subject is able to understand and follow the instructions of the investigator and understand all screening questionnaires. * Subject is in good health. * For participants to be eligible for all tasks of the study, the participant must have a romantic partner and be willing to bring the partner to the study session. Exclusion Criteria: * Tests positive on the 14 panel poly-substance urine drug screen for illicit substances (e.g., marijuana (THC), cocaine (COC), phencyclidine (PCP), amphetamine (AMP), ecstasy (MDMA), methamphetamine (Mamp), opiates (OPI), oxycodone (OXY), methadone (MTD), barbiturates (BAR), benzodiazepines (BZO), buprenorphine (BUP), tricyclic antidepressants (TCA), propoxyphene (PPX)) * Chronic Pain * Do not have the ability to tolerate heat pain applied to the forearm * Have temporary abnormal levels of pain * Have score of \> 19 using the Center for Disease and Epidemiology Depression Scale * Current treatment (e.g., medications or therapy) for psychiatric disorders, including mood, anxiety, substance abuse, Attention-deficit/hyperactivity disorder (ADHD), psychosis; Neurological disorders (e.g., taking dopamine agonists for Parkinson's); Cardiovascular disease or medicatio…

What they're measuring

Change in pain expectation rating score made on a Visual Analog Scale (VAS) after administration of Oxytocin vs. Placebo

Timeframe: Measured during pain tasks at session 1 (within one month of screening survey completion) and 2 which will be within one week of each other.

Change in pain rating score made on a Visual Analog Scale (VAS) after administration of Oxytocin vs. Placebo

Timeframe: Measured during pain tasks at session 1(within one month of screening survey completion) and 2 which will be within one week of each other.

Change in pain unpleasantness rating score during hand holding and control conditions made on a Visual Analog Scale (VAS) after administration of Oxytocin vs. Placebo

Timeframe: Measured during pain tasks at session 1 (within one month of screening survey completion)and 2 which will be within one week of each other.

Trial details

NCT IDNCT03060031

SponsorUniversity of Colorado, Boulder

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-03-05

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