CompletedNot Applicable

Predicting Acute-on-Chronic Liver Failure in Cirrhosis (PREDICT) Study

Austria, Belgium1,314 participantsStarted 2017-03-31

Plain-language summary

The aim of this study is to assess prospectively the critical period prior to the development of Acute-on-Chronic Liver Failure (ACLF) (1), to uncover mechanistic and pathophysiological processes associated with the development and clinical course of ACLF (2) and to identify the precipitating events of ACLF (3).

Who can participate

Age range18 Years

SexALL

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Exclusion criteria

✕. Presence of ACLF at inclusion;
✕. Pregnancy;
✕. Age \<18 years;
✕. Patients with acute or subacute liver failure without underlying cirrhosis;
✕. Patients with cirrhosis who develop decompensation in the postoperative period following partial hepatectomy;
✕. Evidence of current malignancy except for non-melanocytic skin cancer and hepatocellular carcinoma within Milan criteria;
✕. Presence or history of severe extra-hepatic diseases (e.g., chronic renal failure requiring hemodialysis, severe heart disease (NYHA \> II); severe chronic pulmonary disease (GOLD \> III), severe neurological and psychiatric disorders);
✕. HIV-positive patients

What they're measuring

Number of patients developing ACLF within 12 weeks and severity of ACLF development

Timeframe: 12 weeks

Trial details

NCT IDNCT03056612

SponsorJonel Trebicka

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2018-07-31

View on ClinicalTrials.gov More Liver Cirrhosis With Acute Decompensation trials