CompletedNot Applicable

Vascular Health With Immobilization and Exercise Training

Denmark12 participantsStarted 2017-03-15

Plain-language summary

The study includes healthy young habitually active subjects. All subjects are subjected to two weeks of immobilization of one leg followed by four weeks of training of both legs. The subjects are randomized to either one-leg training of the non-immobilized leg during the two-week immobilization period or to no training of the non-immobilized leg during the immobilization period. Measures include skeletal muscle morphology, markers of angiogenesis and apoptosis, muscle metabolic markers, vascular function, vascular proteins and performance.

Who can participate

Age range18 Years – 35 Years

SexALL

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Inclusion Criteria: * Healthy * BMI \<25 * Habitually/moderately physically active Exclusion Criteria: * Known chronic medical disorder * Smoking * Excessive alcohol intake * Known genetic/familial predisposition for thrombosis * Hormonal birth control * High level strength or endurance training on a regular basis

What they're measuring

Angiogenesis

Timeframe: Change from baseline to after 2 weeks of immobilization

Vascular function

Timeframe: Change from baseline to after 2 weeks of immobilization

Angiogenesis

Timeframe: Change from after immobilization to after 4 weeks of training

Vascular function

Timeframe: Change from after immobilization to after 4 weeks of training

Trial details

NCT IDNCT03054376

SponsorUniversity of Copenhagen

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-10-20

View on ClinicalTrials.gov More Immobilization, Tonic trials