WithdrawnNot Applicable

Effects of Intravenous Acetaminophen in Patients Undergoing Thoracoscopic Surgery

Stopped: Not funded

0Started 2018-06-01

Plain-language summary

This is a single-center, randomized, double-blind, placebo-controlled trial. A total of 100 patients, 50 per treatment arm, undergoing minimally invasive thoracic surgery will be randomized 1:1 across 2 treatment arms: Ofiramev® (acetaminophen) injection 1,000 mg (100 mL) plus patient-controlled analgesia (PCA) and 100 mL placebo plus PCA.

Who can participate

Age range18 Years – 99 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18-99 years * Undergo minimally invasive thoracic surgery at UTMB * Weight \> 50 kg * Written informed consent obtained from subject Exclusion Criteria: * Hepatic dysfunction * Renal dysfunction * Chronic alcohol consumption * Acetaminophen sensitivity * Opioid tolerance * History of chronic pain * Vulnerable populations including pregnant and prisoners * Extension into an extrathoracic compartment (i.e. minimally invasive esophagectomy), or concomitant chest wall resection

What they're measuring

The amount of postoperative narcotic used.

Timeframe: Within 7 days of surgery

Trial details

NCT IDNCT03051932

SponsorThe University of Texas Medical Branch, Galveston

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-06-01

View on ClinicalTrials.gov More Post-thoracotomy Pain Syndrome trials