Active — Not RecruitingNot Applicable

Hysterectomy and OPPortunistic SAlpingectomy

Sweden4,400 participantsStarted 2017-06-01

Plain-language summary

HOPPSA is a register based randomized controlled trial (R-RCT), with the objective to examine if opportunistic salpingectomy compared with no salpingectomy, at the time of hysterectomy for a benign reason * has no increased risk of complications * has no negative side effects on ovarian function and subsequent cardiovascular disease or incidence of fractures * implies reduced risk of subsequent ovarian cancer Randomization and follow-up will be conducted within national registers.

Who can participate

Age range20 Years – 54 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Planned hysterectomy for a benign reason * Age \< 55 years at randomization * Willing to be randomized * Vaginal route may be included if the surgeon is confident with performing vaginal salpingectomy. Exclusion Criteria: * Previous bilateral oophorectomy and/or salpingectomy * Planned oophorectomy and/or salpingectomy (for reasons such as already diagnosed adnexal tumor, known carrier of the breast cancer susceptibility gene (BRCA) 1/2 mutation or Lynch syndrome (hereditary nonpolyposis colorectal cancer)) * Non-understanding of the oral or written study information

What they're measuring

Surgical complication - short term primary outcome

Timeframe: Eight weeks post-operative

Change in menopausal symptom score - intermediate term primary outcome

Timeframe: One year after surgery

Epithelial ovarian cancer - long term primary outcome

Timeframe: 10-30 years after surgery

Trial details

NCT IDNCT03045965

SponsorGöteborg University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-06

View on ClinicalTrials.gov More Ovarian Cancer trials