Hysterectomy and OPPortunistic SAlpingectomy (NCT03045965) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Hysterectomy and OPPortunistic SAlpingectomy
Sweden4,400 participantsStarted 2017-06-01
Plain-language summary
HOPPSA is a register based randomized controlled trial (R-RCT), with the objective to examine if opportunistic salpingectomy compared with no salpingectomy, at the time of hysterectomy for a benign reason
* has no increased risk of complications
* has no negative side effects on ovarian function and subsequent cardiovascular disease or incidence of fractures
* implies reduced risk of subsequent ovarian cancer Randomization and follow-up will be conducted within national registers.
Who can participate
Age range
20 Years – 54 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Planned hysterectomy for a benign reason
* Age \< 55 years at randomization
* Willing to be randomized
* Vaginal route may be included if the surgeon is confident with performing vaginal salpingectomy.
Exclusion Criteria:
* Previous bilateral oophorectomy and/or salpingectomy
* Planned oophorectomy and/or salpingectomy (for reasons such as already diagnosed adnexal tumor, known carrier of the breast cancer susceptibility gene (BRCA) 1/2 mutation or Lynch syndrome (hereditary nonpolyposis colorectal cancer))
* Non-understanding of the oral or written study information
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is looking at whether removing the fallopian tubes during a hysterectomy might lower the long-term risk of ovarian cancer — given my situation, is that something worth discussing as part of my planned surgery?
2The study is measuring short-term surgical complications after adding a salpingectomy to a hysterectomy — what does my doctor think the realistic added surgical risk would be for me specifically, compared to hysterectomy alone?
3One of the things this trial tracks is changes in menopausal symptoms after the procedure — how might removing my fallopian tubes at the same time as a hysterectomy affect my hormone levels or menopausal experience, and is that something I should prepare for?
4Since this trial is no longer actively recruiting, the researchers are already collecting follow-up data — does my doctor know of any published or preliminary findings from this study that might help inform whether opportunistic salpingectomy makes sense for me?
5Are there standard-of-care guidelines my doctor already follows around opportunistic salpingectomy during hysterectomy, and how do those compare to what this trial is trying to confirm with longer-term ovarian cancer outcome data?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Surgical complication - short term primary outcome
Timeframe: Eight weeks post-operative
2
Change in menopausal symptom score - intermediate term primary outcome
Timeframe: One year after surgery
3
Epithelial ovarian cancer - long term primary outcome