Congenital lung anomalies include different pathologies such as congenital cystic adenomatoid malformation, pulmonary sequestration, bronchial atresia, emphysema, bronchogenic cyst. They concern less than 1/10000 births and their physiopathological origin is still poorly understood. The main goal of this project is to pool the cases from different swiss centers on a prospective cohort study, first to increase knowledge of clinical and radiological evolution and their correlation with histological data, and second to analyse the pathological embryological mechanism underlying these malformations.
Age range
16 Years
Sex
ALL
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Change in clinical of patients with CLA between different time point
Timeframe: Birth, 1 month of life, 4 months of life, 9-18 months of life, 6 months post surgery, 1 year post surgery, 7 years old, 10 years old, 12 years old
Analysis of CLA physiopathology
Timeframe: samples collected during surgery
Change in lung function
Timeframe: 7 years old,10 years old, 12 years old, 16 years old
Change in Scar aspect and thoracic deformation of patients with CLA between different time point
Timeframe: 6 months post surgery, 1 year post surgery, 7 years old, 10 years old, 12 years old
Change in lung radiological images of patients with CLA between different time point
Timeframe: 1 month of life, 4 months of life, 9-18 months of life, 6 months post surgery, 1 year post surgery, 7 years old, 10 years old, 12 years old
Change in lesion size described by antenatal ultrasound of patients with CLA between different time point
Timeframe: 22, 28, 32 and 37 weeks of gestation
Change in lesion description by antenatal ultrasound of patients with CLA between different time point
Timeframe: 22, 28, 32 and 37 weeks of gestation