Mapping Sound Propagation Through the Human Lung for Better Diagnosis (NCT03043898) | Clinical Trial Compass
TerminatedNot Applicable
Mapping Sound Propagation Through the Human Lung for Better Diagnosis
Stopped: COVID-19
United Kingdom62 participantsStarted 2018-02-14
Plain-language summary
This study investigates the propagation of sound from a source in the chest to the chest wall.
The methodology of the study will be to place a sound source at a known location in the chest and measure the acoustic response on the posterior chest wall with an acoustic sensor array.
The sound source will be created by playing sound down the working channel of a bronchoscope and located anatomically using direct imaging.
Subjects will be selected for the study by asking patients undergoing a bronchoscopy procedure whether they would be willing to take part in the experiment in addition to their standard procedure.
Procedures will take place in the Bronchoscopy Unit at Addenbrooke's hospital in Cambridge. The Unit runs regional speciality clinics in severe chronic obstructive pulmonary disease, asthma, lung cancer, bronchomalacia and interstitial lung disease and has a nationally significant interventional bronchoscopy service.
A subsidiary part of the study (Part A) will collect sound recordings from healthy volunteers and patients with common respiratory diseases using the same acoustic sensor array. This is to create a database of lung sounds and quantify inter-subject variability.
The study will last approximately 30 months.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Participant is willing and able to give informed consent for participation in the study.
* Male of Female, aged 18 years or above.
* Part A(i) Healthy volunteer with no history of smoking, recreational drug use or respiratory disease.
* Part A(ii) Patient admitted to Addenbrooke's with a pulmonary disease resulting in crackles and/or wheezes (as diagnosed by a qualified medical practitioner).
* Part B Patient admitted to Addenbrooke's hospital for a bronchoscopy procedure.
* Part B Appropriate recent imaging available: chest CT within 3 months.
* Part B(i) Lung structure deemed 'normal' by pulmonary physician based on CT scan and medical history.
* Part B(i) Lung structure deemed 'abnormal' by pulmonary physician based on CT scan and medical history.
Exclusion Criteria:
* Informed consent is not given.
* Subject is under 18 years old.
* WHO performance status \>2.
* Subject is pregnant.
* Subject is unable to understand English.
* Part A(i) History of smoking, recreational drug use or respiratory disease.
* Part A(ii) Condition judged to have no effect on breathing sounds. Patient with crackle or wheeze when quota for crackle or wheeze patients respectively is fulfilled.
* Part B Risk associated with prolonging bronchoscopy procedure judged to be too high by medical professional.
* Part B Appropriate recent imaging (chest CT within 3 months) not available.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Comparison of sound propagation through the human chest in subjects with 'normal' and 'abnormal' lung structure.
Timeframe: Will be assessed when all data for Part B of the study has been collected. Up to 30 months.