Stopped: Study halted prematurely due to lack of funding.
This is a hypothesis-generating pilot study. The intent is to model the impact of perioperative practices on the intestinal microbiome and possibly associate these conditions with the final microbiome status (e.g., number of resistance genes and diversity associated with perioperative practices and preoperative microbiome status). Participants will include individuals who are having surgery to either receive or donate a kidney. To determine the diversity change of the intestinal microbiota over time, rectal swabs will be collected before surgery and at several time points after surgery, with the last swab collected 30 days after surgery. This pilot study is to obtain preliminary data to support the rationale and design for a subsequent clinical trial. This study is designed to understand the intestinal microbiota diversity in the setting of renal transplant surgery and the clinical significance of antibiotic use and the associated resistome (collection of all antibiotic resistance genes and precursors within a sample).
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Change in microbiota composition
Timeframe: Baseline to Postoperative Day 30
Change in microbiota diversity
Timeframe: Baseline to Postoperative Day 30
Change in microbiota taxonomy
Timeframe: Baseline to Postoperative Day 30
Change in microbiota resistome
Timeframe: Baseline to Postoperative Day 30