CompletedNot Applicable

Post-Prandial Liver Glucose Metabolism in PCOS

United States19 participantsStarted 2017-04-14

Plain-language summary

The Investigators will measure if hepatic metabolism is upregulated in obese girls with PCOS and hepatic steatosis (HS), compared to PCOS without HS and obese controls without HS.

Who can participate

Age range12 Years – 21 Years

SexFEMALE

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Inclusion criteria

✓. Female
✓. Ages 12-21
✓. Sedentary- less than 2.5 hours of moderate (jogging, swimming etc) exercise a week.
✓. BMI equal or greater than the 90th percentile for age and gender
✓. For PCOS groups:
✓. For PCOS groups:
✓. For non-PCOS groups:

Exclusion criteria

✕. Use of medications known to affect insulin sensitivity:
✕. Currently pregnant or breastfeeding women. Development of pregnancy during the study period will necessitate withdrawal from the study.
✕. Severe illness requiring hospitalization within 60 days
✕. Diabetes, defined as Hemoglobin A1C \> 6.4%
✕. BMI percentile less than the 90th percentile for age and sex.
✕. Weight \>325 lbs or \<84 lbs.
✕. Anemia, defined as Hemoglobin \< 10 mg/dL
✕. Diagnosed major psychiatric or developmental disorder limiting informed consent

What they're measuring

Hepatic Fat Fraction

Timeframe: Measured up to 4 months from enrollment

Trial details

NCT IDNCT03041129

SponsorUniversity of Colorado, Denver

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2018-08-29

Results submitted2022-05-06

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