UnknownPhase 2/3

Role of Anabolic Steroids on Intensive Care Unit-Acquired Weakness

Brazil30 participantsStarted 2016-10

Plain-language summary

The researchers intend to investigate possible anabolic effects of bi-weekly exogenous testosterone administration during intensive care unit (ICU) stay for up to 8 weeks. Control group will receive standard ICU management and will also be followed during ICU stay.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Individuals older than 18 years * Mechanical ventilation by orotracheal tube for more than 14 consecutive days * Mechanical ventilation by tracheostomy for more than 8 consecutive days Exclusion Criteria: * End of life care * Known hypersensitivity to formula * Venous or arterial thrombosis within last 6 months: ischemic stroke, myocardial infarction, acute peripheral arterial occlusion, acute mesenteric ischemia, deep venous thromboembolism, pulmonary embolism * Decompensated congestive heart failure * Acute liver failure or acute on chronic liver failure * Refractory shock (norepinephrine dose \>0.3 mcg/kg/min or equivalent doses of any vasoactive agent) * Platelets below \<20,000 / mm3 without transfusion plan * Personal history of prostate cancer * Primary neuromuscular disorders such as myasthenia gravis, Guillain-Barré syndrome, amyotrophic lateral sclerosis, Duchenne Muscular dystrophy * Current or prior spinal cord injury

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Mechanical ventilation dependence

Timeframe: 8 weeks

Trial details

NCT IDNCT03038919

SponsorHospital de Clinicas de Porto Alegre

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-10

Contact for this trial

Sara C Rosa

+5551997381047 sararosa92@gmail.com

View on ClinicalTrials.gov More Critical Illness Polyneuropathies trials

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.