CompletedPhase 4

Is Vitamin D2 Treatment-associated Decrease in 25(OH)D3 Level a Reciprocal Phenomena?

Saudi Arabia100 participantsStarted 2017-02-15

Plain-language summary

Several studies have demonstrated that D2 treatment is associated with a decrease in 25(OH)D3 level and therefore have proposed that D3 would be preferable in term of raising total 25(OH)D level. The investigators postulate that the D2 treatment-associated decrease in 25(OH)D3 level may be related to an increase in total 25(OH)D level rather than being specific to D2 treatment, and thus there would be a D3 treatment-associated decrease in 25(OH)D2 level. The investigators plan to conduct a double-blind placebo-controlled trial to examine the effect of D3 treatment on 25(OH)D2 level and the effect of D2 treatment on 25(OH)D3 leve

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria: * non-pregnant adults (age ≥18 years) * healthy * total 25(OH)D level between 20 to 65 nmol/L. * living in Riyadh area Exclusion criteria: * consumption of more than one serving of milk daily * taking vitamin D supplements * habitual weekly sun exposure of 10 hours or more * history of granulomatous, liver, or kidney disease * taking anticonvulsants, barbiturates, or steroids

What they're measuring

ANCOVA-adjusted, mean D2-induced change in 25(OH)D3 level group-1

Timeframe: day 28

ANCOVA-adjusted, mean D3-induced change in 25(OH)D2 level in group-2

Timeframe: day 28

Trial details

NCT IDNCT03035084

SponsorKing Faisal Specialist Hospital & Research Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-11-20

View on ClinicalTrials.gov More Vitamin D Deficiency trials