UnknownNot Applicable

Respiratory Muscle Strength and Function in Neuromuscular Disorders and Chronic Obstructive Pulmonary Disease

Germany200 participantsStarted 2016-12-01

Plain-language summary

Using an extensive set of both volitional and non-volitional tests of respiratory muscle function and strength it is the aim of this study to * identify disease-specific patterns of respiratory muscle impairment in different NMD and COPD * establish which set of tests is predictive of sleep-disordered breathing or daytime hypercapnia in patients with NMD or COPD, respectively. * to investigate the decline of respiratory muscle function in patients with progressive NMD and COPD along with sleep studies and capnography

Who can participate

Age range18 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients with NMD (n=100): Amyotrophic lateral sclerosis, Pompe's disease, myotonic dystrophy type 1, limb-girdle muscular dystrophies, spinal muscular atrophy, etc. * patients with chronic obstructive lung disease (n=100) * age 18 - 80 years * written informed consent Exclusion Criteria: * significant chest wall deformity * tracheostomy * inability to sit in the upright position * impaired consciousness * acute or severe medical comorbidity * mechanical ventilation for more than 4 hours during daytime

What they're measuring

Presence of daytime hypercapnia

Timeframe: 1 day

Presence of sleep-disordered breathing

Timeframe: 1 day

Trial details

NCT IDNCT03032562

SponsorUniversität Münster

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-12-31

Contact for this trial

Matthias Boentert, MD

+49-251-83 matthias.boentert@ukmuenster.de

View on ClinicalTrials.gov More Respiratory Muscle Paralysis trials