Alleviating Headache and Pain in GWI With Neuronavigation Guided rTMS (NCT03030794) | Clinical Trial Compass
CompletedNot Applicable
Alleviating Headache and Pain in GWI With Neuronavigation Guided rTMS
United States90 participantsStarted 2016-12
Plain-language summary
This study aims to assess the effect of repetitive transcranial magnetic stimulation (rTMS) on Gulf War illness related headaches and pain.
Who can participate
Age range18 Years – 65 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Criteria for veterans with Gulf War Illness headaches and pain:
Inclusion Criteria:
* Male or female between ages 18-65
* CDC Criteria for GWI
* Kansas Criteria for GWI
* International Headache Society Criteria for Migraine HA w/o aura
* Average Headache Exacerbation Intensity \>3 on 0-10 NPRS
* Average Overall Daily Muscle Pain Intensity \>3 on 0-10 NPRS
* Average Overall Daily Extremities Joint Pain Intensity \>3 on 0-10 NPRS
* Headache Exacerbation/Attack ≥ 3 times/week, lasting \>4 hrs in past 3 months
Exclusion Criteria:
* Pregnancy
* History of pacemaker implant
* Any ferromagnetic (e.g. bullet fragment, shrapnel, device implant) in the brain or body that will prohibit the patients from having a brain MRI
* History of dementia, major psychiatric diseases, or life threatening diseases
* Presence of any other chronic neuropathic pain states such as Complex Regional Pain Syndrome or Painful Peripheral Neuropathy
* History of seizure
* Pending litigation
* Low back pain with mechanical origins such as lumbar radiculopathy or radiculitis or lumbar facet arthropathy
* Lack of ability to understand the experimental protocol and to adequately communicate in English
* History of Traumatic Brain injury
* Chronic Tension or Cluster Headache
* Ongoing Cognitive Rehabilitation or Treatment of PTSD
Criteria for healthy veterans without Gulf War Illness headaches and pain:
Inclusion Criteria:
* Male or female between ages 18-65
* Served at least 30 consecutive days in the Persi…