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Remote Ischemic Preconditioning on Brain Injury in Carotid Endarterectomy

China40 participantsStarted 2017-03-01

Plain-language summary

This is a randomized controlled trial designed to test an intervention (Remote ischemic preconditioning) in patients undergoing carotid endarterectomy (CEA).Remote ischemic preconditioning(RIPC) with transient upper limb ischemia/reperfusion is a novel, simple, cost-free,non-pharmacological and non-invasive strategy.The purpose of this study is to evaluate the effects of Remote Ischaemic Preconditioning on perioperative ischaemic injury in patients undergoing carotid endarterectomy compared to control intervention.The outcomes of interest include neurocognitive function,clinical outcomes,and biomarkers of brain injury.

Who can participate

Age range55 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients undergoing carotid endarterectomy * Patients aged 55 years to 80 years Exclusion Criteria: * Inability to give informed consent * Known Deep venous thrombosis (DVT) in arm * Pre-existing lymphedema or axillary node dissection both arms * Arteriovenous fistula or graft in both arms * Left ventricular ejection fraction less than 50% * Diagnosis of dementia, intellectual disability, or mental illness including depression, anxiety, or schizophrenia

What they're measuring

S100-beta biomarker

Timeframe: 48 hours post surgery

Trial details

NCT IDNCT03027011

SponsorThe Affiliated Hospital of Xuzhou Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-12

Contact for this trial

Chen Xiuxia, MD

+86-18052268332 cxxlxy@sina.com

View on ClinicalTrials.gov More Brain Injuries trials